Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

@article{Laruelle1996SinglePE,
  title={Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.},
  author={Marc Laruelle and Anissa Abi-Dargham and C H van Dyck and Roberto Gil and C. D. D'souza and Joseph Erdos and Elinore McCance and William T Rosenblatt and Christine L Fingado and Sami S. Zoghbi and Ronald M. Baldwin and John P. Seibyl and John H. Krystal and Dennis S. Charney and Robert B. Innis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 17},
  pages={
          9235-40
        }
}
The dopamine hypothesis of schizophrenia proposes that hyperactivity of dopaminergic transmission is associated with this illness, but direct observation of abnormalities of dopamine function in schizophrenia has remained elusive. We used a newly developed single photon emission computerized tomography method to measure amphetamine-induced dopamine release in the striatum of fifteen patients with schizophrenia and fifteen healthy controls. Amphetamine-induced dopamine release was estimated by… CONTINUE READING

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