Single photon emission-computed tomography (SPECT) for functional investigation of the proximal tubule in conscious mice.

@article{Jouret2010SinglePE,
  title={Single photon emission-computed tomography (SPECT) for functional investigation of the proximal tubule in conscious mice.},
  author={François Jouret and St{\'e}phan Walrand and Kleber S. Parreira and Pierre J. Courtoy and Stanislas P. Pauwels and Olivier Devuyst and François Jamar},
  journal={American journal of physiology. Renal physiology},
  year={2010},
  volume={298 2},
  pages={F454-60}
}
Noninvasive analysis of renal function in conscious mice is necessary to optimize the use of mouse models. In this study, we evaluated whether single photon emission-computed tomography (SPECT) using specific radionuclear tracers can be used to analyze changes in renal proximal tubule functions. The tracers included (99m)TC- dimercaptosuccinic acid ((99m)Tc-DMSA), which is used for cortex imaging; (99m)Tc-mercaptoacetyltriglycine ((99m)Tc-MAG3), used for dynamic renography; and (123)I-beta(2… CONTINUE READING