Single perturbed beat vs. steady-state beats for assessing systolic function in the isolated heart.

@article{Campbell1992SinglePB,
  title={Single perturbed beat vs. steady-state beats for assessing systolic function in the isolated heart.},
  author={Kenneth B. Campbell and Hassan Taheri and Robert D. Kirkpatrick and Bryan K. Slinker},
  journal={The American journal of physiology},
  year={1992},
  volume={262 6 Pt 2},
  pages={H1631-9}
}
Single-beat and steady-state techniques for evaluating end-systolic pressure-volume relationship (ESPVR) and Frank-Starling mechanism (FSM) in the crystalloid-perfused isolated rabbit heart were compared. In the single-beat technique, a train of stable isovolumic beats was interrupted with a single perturbed beat that either ejected against various levels of imposed isobaric load (ESPVR protocol) or beat isovolumically against various levels of end-diastolic volume (V(ED); FSM protocol). In… CONTINUE READING