Single-particle tracking of membrane protein diffusion in a potential: simulation, detection, and application to confined diffusion of CFTR Cl- channels.

@article{Jin2007SingleparticleTO,
  title={Single-particle tracking of membrane protein diffusion in a potential: simulation, detection, and application to confined diffusion of CFTR Cl- channels.},
  author={Songwan Jin and Peter M. Haggie and Alan S. Verkman},
  journal={Biophysical journal},
  year={2007},
  volume={93 3},
  pages={1079-88}
}
Confined diffusion of membrane receptors and lipids can result from intramembrane barriers, skeletal interactions, rafts, and other phenomena. We simulated single-particle diffusion in two dimensions in an arbitrary potential, V(r), based on summation of random and potential gradient-driven motions. Algorithms were applied and verified for detection of potential-driven diffusion, and for determination of V(r) from radial particle density distributions, taking into account experimental… CONTINUE READING

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