Single-particle mass spectrometry with arrays of frequency-addressed nanomechanical resonators

@article{Sage2018SingleparticleMS,
  title={Single-particle mass spectrometry with arrays of frequency-addressed nanomechanical resonators},
  author={Eric Sage and Marc Sansa and Shawn Fostner and Martial Defoort and Marc Gely and Akshay K Naik and R. Morel and Laurent Duraffourg and Michael L. Roukes and Thomas Alava and Guillaume Jourdan and {\'E}ric Colinet and Christophe D Masselon and A. Brenac and S{\'e}bastien Hentz},
  journal={Nature Communications},
  year={2018},
  volume={9}
}
  • E. Sage, M. Sansa, +12 authors S. Hentz
  • Published 12 December 2017
  • Materials Science, Physics, Medicine
  • Nature Communications
One of the main challenges to overcome to perform nanomechanical mass spectrometry analysis in a practical time frame stems from the size mismatch between the analyte beam and the small nanomechanical detector area. We report here the demonstration of mass spectrometry with arrays of 20 multiplexed nanomechanical resonators; each resonator is designed with a distinct resonance frequency which becomes its individual address. Mass spectra of metallic aggregates in the MDa range are acquired with… Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Single-protein nanomechanical mass spectrometry in real time
TLDR
The first realization of single-molecule NEMS-based mass spectrometry in real time is reported, which can resolve neutral species, provides resolving power that increases markedly for very large masses, and allows acquisition of spectra, molecule-by-molescule, in real-time. Expand
Neutral particle mass spectrometry with nanomechanical systems
TLDR
It is shown directly that NEMS-MS analysis is insensitive to charge state: the spectrum consists of a single peak whatever the species’ charge state, making it significantly clearer than existing MS analysis. Expand
Mass and stiffness spectrometry of nanoparticles and whole intact bacteria by multimode nanomechanical resonators
TLDR
By using nanomechanical resonators, heavier analytes can be identified by their mass and stiffness by demonstrating the enormous potential of this technology for identification of large biological complexes near their native conformation. Expand
A nanomechanical mass sensor with yoctogram resolution.
TLDR
This unprecedented level of sensitivity allows us to detect adsorption events of naphthalene molecules, and to measure the binding energy of a xenon atom on the nanotube surface, which could have applications in mass spectrometry, magnetometry and surface science. Expand
15.6 A 30-to-80MHz simultaneous dual-mode heterodyne oscillator targeting NEMS array gravimetric sensing applications with a 300zg mass resolution
TLDR
A compact heterodyne self-oscillator analog front-end IC is proposed which performs 1ms simultaneous dual-mode frequency tracking compatible with a “pixel-based” readout scheme to respond to the size, power consumption and resolution constraints linked to NEMS array measurement. Expand
MALDI mass spectrometry imaging in microscope mode with infrared lasers: bypassing the diffraction limits.
TLDR
The use of infrared matrix-assisted laser desorption/ionization coupled with microscope mode mass spectrometry imaging aimed to explore the use of intrinsic water in tissue as a matrix for imaging at spatial resolutions below the diffraction limit of the employed IR optics. Expand
An in-vacuum, pixelated detection system for mass spectrometric analysis and imaging of macromolecules
Abstract The analytical capabilities of a Timepix detection system for mass spectrometry (imaging) are extended by the application of additional acceleration fields. Electrically biasing theExpand
Enumeration of DNA molecules bound to a nanomechanical oscillator.
TLDR
It is demonstrated that highly uniform arrays of nanomechanical resonators can be used to detect the binding of individual DNA molecules through resonant frequency shifts resulting from the added mass of bound analyte. Expand
In-plane nanoelectromechanical resonators based on silicon nanowire piezoresistive detection.
TLDR
An actuation/detection scheme with top-down nanoelectromechanical system (NEMS) for frequency shift based sensing applications with outstanding performance and a improvement of two orders of magnitude in the detection efficiency presented in the state of the art in NEMS fields. Expand
Large-scale integration of nanoelectromechanical systems for gas sensing applications.
TLDR
The utility of integrated NEMS arrays as high-performance chemical vapor sensors is demonstrated, detecting a part-per-billion concentration of a chemical warfare simulant within only a 2 s exposure period. Expand
...
1
2
3
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