Single particle image reconstruction of the human recombinant Kv2.1 channel.

  title={Single particle image reconstruction of the human recombinant Kv2.1 channel.},
  author={Brian D. Adair and Rashmi Nunn and Shannon Lewis and Iain D. Dukes and Louis Philipson and Mark Yeager},
  journal={Biophysical journal},
  volume={94 6},
Kv2.1 channels are widely expressed in neuronal and endocrine cells and generate slowly activating K+ currents, which contribute to repolarization in these cells. Kv2.1 is expressed at high levels in the mammalian brain and is a major component of the delayed rectifier current in the hippocampus. In addition, Kv2.1 channels have been implicated in the regulation of membrane repolarization, cytoplasmic calcium levels, and insulin secretion in pancreatic beta-cells. They are therefore an… CONTINUE READING
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