Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers.

  title={Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers.},
  author={Marcus Kostka and Tobias Hoegen and Karin M Danzer and Johannes Levin and Matthias Habeck and Andreas Wirth and Richard Wagner and Charles G. Glabe and Sabine Finger and Udo Heinzelmann and Patrick Garidel and Wenzhen Duan and Christopher A. Ross and Hans Kretzschmar and Armin Giese},
  journal={The Journal of biological chemistry},
  volume={283 16},
Aggregation of alpha-synuclein is a key event in several neurodegenerative diseases, including Parkinson disease. Recent findings suggest that oligomers represent the principal toxic aggregate species. Using confocal single-molecule fluorescence techniques, such as scanning for intensely fluorescent targets (SIFT) and atomic force microscopy, we monitored alpha-synuclein oligomer formation at the single particle level. Organic solvents were used to trigger aggregation, which resulted in small… CONTINUE READING


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