Single oral doses of 13C forms of pteroylmonoglutamic acid and 5-formyltetrahydrofolic acid elicit differences in short-term kinetics of labelled and unlabelled folates in plasma: potential problems in interpretation of folate bioavailability studies.

@article{Wright2003SingleOD,
  title={Single oral doses of 13C forms of pteroylmonoglutamic acid and 5-formyltetrahydrofolic acid elicit differences in short-term kinetics of labelled and unlabelled folates in plasma: potential problems in interpretation of folate bioavailability studies.},
  author={A. J. Wright and P. Finglas and J. Dainty and D. Hart and C. Wolfe and S. Southon and J. F. Gregory},
  journal={The British journal of nutrition},
  year={2003},
  volume={90 2},
  pages={
          363-71
        }
}
  • A. J. Wright, P. Finglas, +4 authors J. F. Gregory
  • Published 2003
  • Chemistry, Medicine
  • The British journal of nutrition
  • Single (13)C6-labelled doses of pteroylmonoglutamic acid (PteGlu; 634 nmol) or 5-formyltetrahydrofolic acid (431-569 nmol) were given to fasted adult volunteers, and the rise in total and (13)C-labelled plasma 5-methyltetrahydrofolic acid metabolite monitored over 8 h by HPLC and liquid chromatography-MS. The dose-adjusted area under the curve (AUC) for total (labelled plus unlabelled) plasma 5-methyltetrahydrofolic acid following a 5-formyltetrahydrofolic acid test dose was 155 % that obtained… CONTINUE READING
    65 Citations

    Figures, Tables, and Topics from this paper.

    The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men.
    • 63
    • PDF
    L-ascorbic acid improves the serum folate response to an oral dose of [6S]-5-methyltetrahydrofolic acid in healthy men
    • 13
    • PDF
    Estimation of the 5-methyltetrahydrofolate apparent volume of distribution in humans.
    • 3
    • PDF

    References

    SHOWING 1-10 OF 47 REFERENCES
    Relative bioavailability of deuterium-labeled monoglutamyl tetrahydrofolates and folic acid in human subjects.
    • 61
    • Highly Influential
    • PDF
    In vivo characterization of the absorption and biotransformation of pteroylmonoglutamic acid in man: a model for future studies.
    • 45
    Preparation of (6S)-5-formyltetrahydrofolate labeled at high specific activity with 14C and 3H.
    • 8
    Use of an oral/intravenous dual-label stable-isotope protocol to determine folic acid bioavailability from fortified cereal grain foods in women.
    • 34
    • PDF
    Ingestion and absorption of naturally occurring pteroylmonoglutamates (folates) in man.
    • 39