Single oral dose study of two isosorbide-based aspirin prodrugs in the dog.

@article{Gilmer2003SingleOD,
  title={Single oral dose study of two isosorbide-based aspirin prodrugs in the dog.},
  author={John F. Gilmer and Michael A. Murphy and Jean A Shannon and Colm G Breen and Sheila A Ryder and John M Clancy},
  journal={The Journal of pharmacy and pharmacology},
  year={2003},
  volume={55 10},
  pages={1351-7}
}
The objective of this study was to compare two aspirin prodrugs, isosorbide diaspirinate (ISDA) and a nitroaspirin (ISMNA), with aspirin in terms of effects on dog platelet function after administration of a single oral dose. Groups of six dogs were administered ISDA (2mg kg(-1)), ISMNA (4 mg kg(-1)) or aspirin (2mg kg(-1)). Blood was sampled at 1, 2, 4, 8, 12 and 24 h post-dosing and evaluated for capacity to generate post-clotting thromboxane (TX)B2. The aggregation response to arachidonic… CONTINUE READING