Single oral challenge by advanced glycation end products acutely impairs endothelial function in diabetic and nondiabetic subjects.

@article{Uribarri2007SingleOC,
  title={Single oral challenge by advanced glycation end products acutely impairs endothelial function in diabetic and nondiabetic subjects.},
  author={Jaime Uribarri and Alin O Stirban and Denise Sander and Weijing Cai and Monica Negrean and Cristina E Buenting and Theodore Koschinsky and Helen Vlassara},
  journal={Diabetes care},
  year={2007},
  volume={30 10},
  pages={
          2579-82
        }
}
OBJECTIVE The current study was designed to test the acute effects of dietary advanced glycation end products (AGEs) on endothelial function of diabetic and nondiabetic subjects. RESEARCH DESIGN AND METHODS Flow-mediated dilation (FMD) of the brachial artery and serum levels of AGEs, plasminogen activator inhibitor 1 (PAI-1), vascular cell adhesion molecule 1 (VCAM-1), and glucose were assessed before and after a single oral AGE challenge (approximately 1.8 x 10(6) AGE units) in 44 diabetic… CONTINUE READING
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