Single or repeated electroconvulsive shocks alter the levels of prodynorphin and proenkephalin mRNAs in rat brain.

@article{Xie1989SingleOR,
  title={Single or repeated electroconvulsive shocks alter the levels of prodynorphin and proenkephalin mRNAs in rat brain.},
  author={C W Xie and Phil H. Lee and Koji Takeuchi and V V Owyang and Seung Jae Li and Jim Douglass and Jau Shong Hong},
  journal={Brain research. Molecular brain research},
  year={1989},
  volume={6 1},
  pages={11-9}
}
The effects of single or repeated electroconvulsive shocks (ECS) on the abundance of mRNAs coding for prodynorphin (DYN mRNA) and proenkephalin (EK mRNA) in rat brain were investigated. Rats were given either a single ECS and sacrificed at 0.5, 2, 6, or 12 h post-shock (expt. I), or were subjected to ECS for 1, 3 or 6 days and killed 24 h after the last shock (expt. II). The amounts of DYN mRNA and EK mRNA were measured in several brain regions using RNA blot analysis. In expt. I, a biphasic… CONTINUE READING
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