Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation

@article{Preissl2018SinglenucleusAO,
  title={Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation},
  author={Sebastian Preissl and Rongxin Fang and Hui Huang and Yuan Zhao and Ramya Raviram and David U Gorkin and Yanxiao Zhang and Brandon Chin Sos and Veena Afzal and Diane E. Dickel and S. N. Kuan and Axel Visel and Len A. Pennacchio and Kun Qiu Zhang and Bing Ren},
  journal={Nature Neuroscience},
  year={2018},
  volume={21},
  pages={432-439}
}
Analysis of chromatin accessibility can reveal transcriptional regulatory sequences, but heterogeneity of primary tissues poses a significant challenge in mapping the precise chromatin landscape in specific cell types. Here we report single-nucleus ATAC-seq, a combinatorial barcoding-assisted single-cell assay for transposase-accessible chromatin that is… CONTINUE READING