Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness

@article{Hao2005SinglenucleotidePO,
  title={Single-nucleotide polymorphisms of the KCNS3 gene are significantly associated with airway hyperresponsiveness},
  author={Ke Hao and Tianhua Niu and Xin Xu and Zhi-an Fang and Xiping Xu},
  journal={Human Genetics},
  year={2005},
  volume={116},
  pages={378-383}
}
Airway hyperresponsiveness (AHR) is one of the major clinical symptoms and intermediate phenotypes of asthma. A recent genome-wide search for asthma quantitative trait loci has revealed a significant linkage signal between a p-terminal region of chromosome 2 and AHR. Thus, the gene encoding the potassium voltage-gated channel delayed-rectifier protein S3 (KCNS3) in this region is considered a positional candidate for asthma. We have evaluated a total of 12 single-nucleotide polymorphisms (SNPs… 
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