Single-nucleotide polymorphisms of VEGF gene are associated with risk of congenital valvuloseptal heart defects.

@article{Vannay2006SinglenucleotidePO,
  title={Single-nucleotide polymorphisms of VEGF gene are associated with risk of congenital valvuloseptal heart defects.},
  author={{\'A}d{\'a}m Vannay and Barna V{\'a}s{\'a}rhelyi and M{\'a}ria K{\"o}rnyei and Andr{\'a}s Treszl and Gergely Kozma and Balazs Gy{\"o}rffy and Tivadar Tulassay and Endre Sulyok},
  journal={American heart journal},
  year={2006},
  volume={151 4},
  pages={878-81}
}
BACKGROUND Disturbed vascular endothelial growth factor (VEGF) production during early heart morphogenesis causes endocardial cushion malformation, which results in congenital heart disease (CHD). We tested whether functional VEGF -460T/C and +405G/C polymorphisms that have an impact on VEGF levels were associated with CHD. METHODS Dried blood samples were collected from 102 CHD children and 112 healthy control neonates. Genotyping was done with polymerase chain reaction-restriction fragment… CONTINUE READING
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