Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility.

  title={Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility.},
  author={Milena Sabrina Nicoloso and Hao Sun and Riccardo Spizzo and Hyunsoo Kim and Priyankara Wickramasinghe and Masayoshi Shimizu and Sylwia E. Wojcik and Jana Ferdin and Tanja Kunej and Lianchun Xiao and Siranoush Manoukian and Giorgio Secreto and Fernando Ravagnani and Xue-Mei Wang and Paolo Radice and Carlo M. Croce and Ramana V. Davuluri and George A. Calin},
  journal={Cancer research},
  volume={70 7},
Single-nucleotide polymorphisms (SNP) associated with polygenetic disorders, such as breast cancer (BC), can create, destroy, or modify microRNA (miRNA) binding sites; however, the extent to which SNPs interfere with miRNA gene regulation and affect cancer susceptibility remains largely unknown. We hypothesize that disruption of miRNA target binding by SNPs is a widespread mechanism relevant to cancer susceptibility. To test this, we analyzed SNPs known to be associated with BC risk, in silico… CONTINUE READING

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