Single-nucleotide polymorphisms in vascular Ca2+-activated K+-channel genes and cardiovascular disease

@article{Khler2009SinglenucleotidePI,
  title={Single-nucleotide polymorphisms in vascular Ca2+-activated K+-channel genes and cardiovascular disease},
  author={Ralf K{\"o}hler},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2009},
  volume={460},
  pages={343-351}
}
In the cardiovascular system, Ca2+-activated K+-channels (KCa) are considered crucial mediators in the control of vascular tone and blood pressure by modulating the membrane potential and shaping Ca2+-dependent contraction. Vascular smooth muscle cells express the BKCa channel which fine-tunes contractility by providing a negative feedback on Ca2+-elevations. BKCa channel's ion-conducting α-subunit is encoded by the KCa1.1 gene, and the accessory and Ca2+-sensitivity modulating β1-subunit is… CONTINUE READING