Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations.

@article{Tanaka2003SingleNP,
  title={Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations.},
  author={H. Tanaka and Y. Miyagawa and A. Tsujimura and K. Matsumiya and A. Okuyama and Y. Nishimune},
  journal={Molecular human reproduction},
  year={2003},
  volume={9 2},
  pages={
          69-73
        }
}
  • H. Tanaka, Y. Miyagawa, +3 authors Y. Nishimune
  • Published 2003
  • Biology, Medicine
  • Molecular human reproduction
  • Although various genetic factors have been implicated in human male infertility, the causative genes for the different types of idiopathic male infertility have not been elucidated. Protamines, which are the major DNA-binding proteins in the sperm nucleus, package the DNA into the sperm head. Analysis of the human protamine-1 (PRM1) and -2 (PRM2) gene sequences in 226 sterile male patients and in 270 proven-fertile male volunteers revealed four single nucleotide polymorphisms (SNPs) in the PRM1… CONTINUE READING
    98 Citations
    An SNP in protamine 1: a possible genetic cause of male infertility?
    • 87
    Mutations in the protamine locus: association with spermatogenic failure?
    • 46
    • Highly Influenced
    • PDF
    Polymorphisms, haplotypes and mutations in the protamine 1 and 2 genes.
    • 33
    Association study of protamine 2 (PRM2) gene polymorphism with male infertility in Chinese Han population
    • 5
    Genetic Polymorphisms in PRM1, PRM2, and YBX2 Genes are Associated with Male Factor Infertility.
    • 6
    Mutations in the protamine 1 gene associated with male infertility.
    • 72
    • PDF

    References

    SHOWING 1-10 OF 29 REFERENCES
    Linkage between male infertility and trinucleotide repeat expansion in the androgen-receptor gene
    • 261
    Haploinsufficiency of protamine-1 or -2 causes infertility in mice
    • 456
    Protein and DNA contents in sperm from an infertile human male possessing protamine defects that vary over time
    • 56
    Association of molecular variants of luteinizing hormone with male infertility.
    • 50
    • PDF