Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations.

  title={Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations.},
  author={H. Tanaka and Y. Miyagawa and A. Tsujimura and K. Matsumiya and A. Okuyama and Y. Nishimune},
  journal={Molecular human reproduction},
  volume={9 2},
  • H. Tanaka, Y. Miyagawa, +3 authors Y. Nishimune
  • Published 2003
  • Biology, Medicine
  • Molecular human reproduction
  • Although various genetic factors have been implicated in human male infertility, the causative genes for the different types of idiopathic male infertility have not been elucidated. Protamines, which are the major DNA-binding proteins in the sperm nucleus, package the DNA into the sperm head. Analysis of the human protamine-1 (PRM1) and -2 (PRM2) gene sequences in 226 sterile male patients and in 270 proven-fertile male volunteers revealed four single nucleotide polymorphisms (SNPs) in the PRM1… CONTINUE READING
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