Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans.

  title={Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans.},
  author={Hey-Joo Kang and Zhaohui Feng and Yvonne Sun and Gurinder S. Atwal and Maureen E Murphy and Timothy R. Rebbeck and Zev Rosenwaks and Arnold J. Levine and Wenwei Hu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 24},
The tumor suppressor protein p53 plays an important role in maternal reproduction in mice through transcriptional regulation of leukemia inhibitory factor (LIF), a cytokine crucial for blastocyst implantation. To determine whether these observations could be extended to humans, a list of single-nucleotide polymorphisms (SNPs) in the p53 pathway that can modify the function of p53 was assembled and used to study their impact on human fertility. The p53 allele encoding proline at codon 72 (P72… CONTINUE READING
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