Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans.

@article{Kang2009SinglenucleotidePI,
  title={Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans.},
  author={Hey-Joo Kang and Zhaohui Feng and Yvonne Sun and Gurinder S. Atwal and Maureen E Murphy and Timothy R. Rebbeck and Zev Rosenwaks and Arnold J. Levine and Wenwei Hu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 24},
  pages={9761-6}
}
The tumor suppressor protein p53 plays an important role in maternal reproduction in mice through transcriptional regulation of leukemia inhibitory factor (LIF), a cytokine crucial for blastocyst implantation. To determine whether these observations could be extended to humans, a list of single-nucleotide polymorphisms (SNPs) in the p53 pathway that can modify the function of p53 was assembled and used to study their impact on human fertility. The p53 allele encoding proline at codon 72 (P72… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 63 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 22 references

Evolutionary selection and altered tumor formation of genetic variants in the human Mdm4 oncogene

  • GS Atwal
  • Proc Natl Acad Sci USA,
  • 2009

Similar Papers

Loading similar papers…