Single nucleotide polymorphisms in the imprinted bovine insulin-like growth factor 2 receptor gene (IGF2R) are associated with body size traits in Irish Holstein-Friesian cattle.

@article{Berkowicz2012SingleNP,
  title={Single nucleotide polymorphisms in the imprinted bovine insulin-like growth factor 2 receptor gene (IGF2R) are associated with body size traits in Irish Holstein-Friesian cattle.},
  author={Erik W Berkowicz and David A. Magee and Donagh P Berry and Klaudia M Sikora and Dawn J. Howard and Michael P. Mullen and Ross D Evans and Charles Spillane and David E. MacHugh},
  journal={Animal genetics},
  year={2012},
  volume={43 1},
  pages={81-7}
}
The regulation of the bioavailability of insulin-like growth factors (IGFs) is critical for normal mammalian growth and development. The imprinted insulin-like growth factor 2 receptor gene (IGF2R) encodes a transmembrane protein receptor that acts to sequester and degrade excess circulating insulin-like growth factor 2 (IGF-II) - a potent foetal mitogen - and is considered an important inhibitor of growth. Consequently, IGF2R may serve as a candidate gene underlying important growth- and body… CONTINUE READING