Single nucleotide polymorphisms in the hypoxia-inducible factor-1alpha (HIF-1alpha) gene in human sporadic breast cancer.

@article{Apaydin2008SingleNP,
  title={Single nucleotide polymorphisms in the hypoxia-inducible factor-1alpha (HIF-1alpha) gene in human sporadic breast cancer.},
  author={Isil Apaydin and Ece Konac and Hacer Ilke Onen and Murat Akbaba and Ercument H Tekin and Abdullah Ekmekçi},
  journal={Archives of medical research},
  year={2008},
  volume={39 3},
  pages={338-45}
}
BACKGROUND DNA sequence variations in hypoxia-inducible factor-1alpha (HIF-1alpha) gene, which have been demonstrated to be correlated with tumor angiogenesis, may yield changes both in the production outcomes and in the activities of the gene. In this study, we investigated the relationship between three single nucleotide polymorphisms (SNPs) [C1772T and G1790A in exon 12 and C111A in exon 2 of the HIF-1alpha gene] in the HIF-1alpha gene coding regions and development of sporadic breast cancer… CONTINUE READING
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