Single nucleotide polymorphisms and haplotypes of histamine N-methyltransferase in patients with gastric ulcer

@article{Chen2004SingleNP,
  title={Single nucleotide polymorphisms and haplotypes of histamine N-methyltransferase in patients with gastric ulcer},
  author={G. Chen and B. Zhu and W. Nie and Z. Xu and Z. Tan and G. Zhou and J. Liu and W. Wang and H. Zhou},
  journal={Inflammation Research},
  year={2004},
  volume={53},
  pages={484-488}
}
  • G. Chen, B. Zhu, +6 authors H. Zhou
  • Published 2004
  • Medicine
  • Inflammation Research
  • Abstract.Introduction: Histamine plays a crucial role in the regulation of gastric acid secretion, which is involved in the pathogenesis of peptic ulcer. Histamine N-methyltransferase (HNMT) is the major metabolizing enzyme for histamine inactivation in human stomach.Objective: This study aims to determine whether there exists a relationship between HNMT gene polymorphisms and the risk for gastric ulcer (GU).Methods: 118 GU patients and 154 ethnically matched control subjects were enrolled and… CONTINUE READING
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