Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.

@article{Stankov2008SinglenucleotidePR,
  title={Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.},
  author={Alena Stan{\vc}{\'a}kov{\'a} and Jussi Pihlajam{\"a}ki and Johanna Kuusisto and Norbert Stefan and Andreas Fritsche and H. U. H{\"a}ring and Francesco Andreozzi and Elena Succurro and Giorgio Sesti and Trine Well\ov Boesgaard and Torben Hansen and Oluf Pedersen and Per Anders Jansson and Ann Hammarstedt and Ulf Smith and Markku Laakso},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2008},
  volume={93 5},
  pages={1924-30}
}
CONTEXT CDKAL1 is a recently discovered susceptibility gene for type 2 diabetes. OBJECTIVE Our objective was to investigate the impact of rs7754840 of CDKAL1 on insulin secretion, insulin sensitivity, and risk of type 2 diabetes. DESIGN AND SETTINGS Study 1 (the EUGENE2 study) was a cross-sectional study including subjects from five white populations in Europe (Denmark, Finland, Germany, Italy, and Sweden). Study 2 is an ongoing prospective study of Finnish men. PARTICIPANTS In study 1… CONTINUE READING

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CDKAL1 and type 2 diabetes: a global meta-analysis.

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