Single nucleotide polymorphism in the MMP-9 gene is associated with susceptibility to develop multiple sclerosis in an Italian case-control study.

@article{Russa2010SingleNP,
  title={Single nucleotide polymorphism in the MMP-9 gene is associated with susceptibility to develop multiple sclerosis in an Italian case-control study.},
  author={Antonella La Russa and Rita Cittadella and Elvira Valeria De Marco and Paola Valentino and Virginia Andreoli and Francesca Trecroci and Valeria K Latorre and Antonio Gambardella and Aldo Quattrone},
  journal={Journal of neuroimmunology},
  year={2010},
  volume={225 1-2},
  pages={175-9}
}
To investigate the role of the matrix metalloproteinase-9 gene (MMP-9) in multiple sclerosis (MS), we analyzed the functional -1562C/T and -90 (CA)(n) repeat polymorphisms in 243 Italian patients with MS and 173 healthy controls. A significant increase of the -1562T allele carriers was found in patients with MS compared to controls. Moreover, haplotype… CONTINUE READING