• Medicine
  • Published in Human molecular genetics 2000

Single nucleotide polymorphism and linkage disequilibrium within the TCR alpha/delta locus.

@article{Moffatt2000SingleNP,
  title={Single nucleotide polymorphism and linkage disequilibrium within the TCR alpha/delta locus.},
  author={Miriam F Moffatt and James A Traherne and Gonçalo R. Abecasis and William O. C. Cookson},
  journal={Human molecular genetics},
  year={2000},
  volume={9 7},
  pages={
          1011-9
        }
}
Much attention is being given to the identification of common disease genes through whole-genome linkage disequilibrium (LD) screens with single nucleotide polymorphisms (SNPs). Simulation studies have suggested that useful LD is unlikely to extend beyond 3 kb, and that > 500,000 SNPs may be needed for comprehensive coverage of the genome. The TCR alpha/delta locus on chromosome 14q contains many V, J and D segments that combine with constant domains to produce either an alpha or a delta chain… CONTINUE READING

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