Single nucleotide polymorphism analysis of the follicle-stimulating hormone (FSH) receptor in Japanese with male infertility: identification of codon combination with heterozygous variations of the two discrete FSH receptor gene.

@article{Shimoda2009SingleNP,
  title={Single nucleotide polymorphism analysis of the follicle-stimulating hormone (FSH) receptor in Japanese with male infertility: identification of codon combination with heterozygous variations of the two discrete FSH receptor gene.},
  author={Chiharu Shimoda and Eitetsu Koh and Kenrou Yamamoto and Futoshi Matsui and Kazuhiro Sugimoto and Ho-Su Sin and Yuji Maeda and Jiro Kanaya and Atsumi Yoshida and Mikio Namiki},
  journal={Endocrine journal},
  year={2009},
  volume={56 7},
  pages={
          859-65
        }
}
AIMS Dysfunction of the FSH receptor (FSHR) may be involved in some form of male infertility with azoospermia or oligozoospermia. We assessed the discrete codon combination with homo/heterozygous variation of the exon 10 in the FSHR gene. METHODS The genotype of codon 307 and codon 680 were analysed in 352 patients with idiopathic male infertility and 145 men with proven fertility. RESULTS AND CONCLUSION There was no significant difference in the distributions of each homozygous codon 307… CONTINUE READING

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