Single nucleotide polymorphism (SNP) of the endothelial nitric oxide synthase (eNOS) gene (Glu298Asp variant) in infertile men with asthenozoospermia.

@article{Buldreghini2010SingleNP,
  title={Single nucleotide polymorphism (SNP) of the endothelial nitric oxide synthase (eNOS) gene (Glu298Asp variant) in infertile men with asthenozoospermia.},
  author={Eddi Buldreghini and Reda Z Mahfouz and Arianna Vignini and Laura Mazzanti and Giuseppe Ricciardo-Lamonica and Andrea Lenzi and Ashok Agarwal and Giancarlo Balercia},
  journal={Journal of andrology},
  year={2010},
  volume={31 5},
  pages={
          482-8
        }
}
The objective of this study was to elucidate the missense Glu298Asp polymorphism within exon 7 of the endothelial nitric oxide synthase (eNOS) gene in infertile men with asthenozoospermia and its potential role in sperm motility. [] Key Method In this prospective controlled study conducted in our andrology unit, we investigated the frequency of the 894G>T polymorphism (Glu298Asp variant) within exon 7 of the eNOS gene in 70 infertile men and 60 healthy men.
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Analysis of endothelial nitric oxide synthase (eNOS) G894T polymorphism and semen parameters in a Chinese Han population
TLDR
The study indicated that eNOS gene G894T polymorphism may not have an adverse effect on semen parameters in a Chinese Han population.
Endothelial nitric oxide synthase gene polymorphism relationship with semen parameters and oxidative stress in infertile oligoasthenoteratozoospermic men.
Endothelial Nitric Oxide Synthase (eNOS) T-786C, 4a4b, and G894T Polymorphisms and Male Infertility: Study for Idiopathic Asthenozoospermia and Meta-Analysis1
ABSTRACT Recent studies on the eNOS gene and male infertility show that expression of eNOS regulates normal spermatogenesis in the testis, and the eNOS gene variants (T-786C, 4a4b, and G894T) are…
Association of nitric oxide synthase 3 gene rs1799983 G/T polymorphism with idiopathic asthenozoospermia in Iranian Azeri males: a case-control study
TLDR
It is demonstrated that NOS3 gene rs1799983 G/T polymorphism was associated with AZS in Iranian Azeri men, however, more studies on different geographic areas, races and ethnicities are required.
Synergistic effect of androgen receptor (CAG repeat length) and endothelial nitric oxide synthase (Glu298Asp variant) gene polymorphisms on seminal parameters in men with idiopathic oligoasthenozoospermia
TLDR
The association between AR and eNOS genes polymorphisms is verified, considered both separately and combined, in order to assess the possible synergistic effect of the two genetic variations on seminal parameters.
Variants in endothelial nitric oxide synthase (eNOS) gene in idiopathic infertile Brazilian men.
Designing and Validation of One-Step T-ARMS-PCR for Genotyping the eNOS rs1799983 SNP.
TLDR
This is the first work that describes a rapid, relatively cheap, high throughput detection of G894T polymorphism in eNOS that can be used in large scale clinical studies.
THE ROLE OF ENOSGENE POLYMORPHISM IN THE RISK OF ASTHENOZOOSPERMIA INCIDENCE IN A SAMPLE OF IRAQI PATIENTS
TLDR
The relationship of eNOS polymorphism (rs1799983 T>A)in exon 8, was studied in 50 asthenozoospermic patients and 50 fertile men and showed no risk factor to cause infertility.
Genetic Variants in Nitric Oxide Synthase Genes and the Risk of Male Infertility in a Chinese Population: A Case-Control Study
TLDR
Of five NOS gene polymorphisms investigated in the present study, NOS3 rs1799983 might cause oxidative sperm DNA damage, thereby contributing to male infertility.
Genetic variants of eNOS gene may modify the susceptibility to idiopathic male infertility
TLDR
It is suggested that the variants of eNOS gene may modify the susceptibility to male infertility with impaired spermatogenesis, as well as a protective factor for male infertility.
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References

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TLDR
Findings suggest that the T allele, encoding aspartic acid, of the Glu298Asp polymorphism of the NOS3 may be associated with advanced stage endometriosis in the Korean population.
ENDOTHELIAL NITRIC OXIDE SYNTHASE G894T (GLU298ASP) POLYMORPHISM IS ASSOCIATED WITH HYPOTENSION IN PATIENTS WITH E. coli BACTEREMIA BUT NOT IN BACTEREMIA CAUSED BY A GRAM-POSITIVE ORGANISM
TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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