Single-nucleotide gene polymorphisms involving cell death pathways: a study of Chinese patients with lumbar disc herniation.

@article{Sun2013SinglenucleotideGP,
  title={Single-nucleotide gene polymorphisms involving cell death pathways: a study of Chinese patients with lumbar disc herniation.},
  author={Zheng-ming Sun and Ming Ling and Yanhai Chang and Yuping Huo and Guang Yang and Yuqiang Ji and Yaping Li},
  journal={Connective tissue research},
  year={2013},
  volume={54 1},
  pages={55-61}
}
OBJECTIVE To evaluate the effect of polymorphisms of death pathway genes FAS and FASL on the risk of developing lumbar disc herniation (LDH) in a Northern Chinese population. BACKGROUND DATA The FAS receptor-ligand system plays a key role to regulate apoptosis of cell. There is evidence that the apoptosis-mediated FAS receptor-ligand system is involved in the pathogenesis of disc degeneration. Some research considered single-nucleotide polymorphisms of FAS-1377G/A, FAS-670A/G, FASL-844T/C… CONTINUE READING
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