Single nucleotide change in the cannabinoid receptor-1 (CNR1) gene in colorectal cancer outcome.

@article{Bedoya2009SingleNC,
  title={Single nucleotide change in the cannabinoid receptor-1 (CNR1) gene in colorectal cancer outcome.},
  author={Fernando Bedoya and Juan C. Rubio and Carlos Morales-Gutierrez and Alfredo Abad-Barahona and David Lora Pablos and Juan Carlos Meneu and Enrique Moreno-Gonz{\'a}lez and Rafael Enr{\'i}quez de Salamanca and Irene Vegh},
  journal={Oncology},
  year={2009},
  volume={76 6},
  pages={435-41}
}
The cannabinoid receptor-1 (CNR-1) and endogenous agonists of this receptor are present in the central and peripheral nervous systems including the gastrointestinal nervous system. The surgically rejected specimens of human colorectal cancers and paired normal tissues were studied to detect mutations in the CNR1 gene by sequencing method. The results were compared to clinicopathological parameters and correlated with overall survival time. Sixty-three colorectal cancer patients, who underwent… CONTINUE READING
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