Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling.

Abstract

The RAF serine/threonine kinases regulate cell growth through the MAPK pathway, and are targeted by small-molecule RAF inhibitors (RAFis) in human cancer. It is now apparent that protein multimers play an important role in RAF activation and tumor response to RAFis. However, the exact stoichiometry and cellular location of these multimers remain unclear… (More)
DOI: 10.1073/pnas.1318188110

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