Single molecule study of the intrinsically disordered FG-repeat nucleoporin 153.

@article{Milles2011SingleMS,
  title={Single molecule study of the intrinsically disordered FG-repeat nucleoporin 153.},
  author={Sigrid Milles and Edward A Lemke},
  journal={Biophysical journal},
  year={2011},
  volume={101 7},
  pages={1710-9}
}
Nucleoporins (Nups), which are intrinsically disordered, form a selectivity filter inside the nuclear pore complex, taking a central role in the vital nucleocytoplasmic transport mechanism. These Nups display a complex and nonrandom amino-acid architecture of phenylalanine glycine (FG)-repeat clusters and intra-FG linkers. How such heterogeneous sequence composition relates to function and could give rise to a transport mechanism is still unclear. Here we describe a combined chemical biology… CONTINUE READING

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