Single-molecule studies of riboswitch folding.

  title={Single-molecule studies of riboswitch folding.},
  author={Andrew Savinov and Christian P{\'e}rez and Steven M. Block},
  journal={Biochimica et biophysica acta},
  volume={1839 10},
The folding dynamics of riboswitches are central to their ability to modulate gene expression in response to environmental cues. In most cases, a structural competition between the formation of a ligand-binding aptamer and an expression platform (or some other competing off-state) determines the regulatory outcome. Here, we review single-molecule studies of riboswitch folding and function, predominantly carried out using single-molecule FRET or optical trapping approaches. Recent results have… CONTINUE READING
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