Single-molecule mechanical measurements of the hyaluronan-aggrecan bottlebrush

  title={Single-molecule mechanical measurements of the hyaluronan-aggrecan bottlebrush},
  author={S. Innes-Gold and J. Berezney and O. Saleh},
  journal={Biophysical Journal},
Large bottlebrush complexes formed from the polysaccharide hyaluronan (HA) and the proteoglycan aggrecan contribute to cartilage compression resistance and are necessary for healthy joint function. A variety of mechanical forces act on these complexes in the cartilage extracellular matrix, motivating the need for a quantitative description of their structure and mechanical response. Studies using electron microscopy have imaged the HA-aggrecan brush but require adsorption to a surface… Expand
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