Single-molecule measurements of the CCR5 mRNA unfolding pathways.

  title={Single-molecule measurements of the CCR5 mRNA unfolding pathways.},
  author={Michel de Messieres and Jen-Chien Jack Chang and Ashton T Belew and Arturas Meskauskas and Jonathan D. Dinman and Arthur La Porta},
  journal={Biophysical journal},
  volume={106 1},
Secondary or tertiary structure in an mRNA, such as a pseudoknot, can create a physical barrier that requires the ribosome to generate additional force to translocate. The presence of such a barrier can dramatically increase the probability that the ribosome will shift into an alternate reading frame, in which a different set of codons is recognized. The detailed biophysical mechanism by which frameshifting is induced remains unknown. Here we employ optical trapping techniques to investigate… CONTINUE READING
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