Single molecule-level detection and long read-based phasing of epigenetic variations in bacterial methylomes


Beyond its role in host defense, bacterial DNA methylation also plays important roles in the regulation of gene expression, virulence and antibiotic resistance. Bacterial cells in a clonal population can generate epigenetic heterogeneity to increase population-level phenotypic plasticity. Single molecule, real-time (SMRT) sequencing enables the detection of… (More)
DOI: 10.1038/ncomms8438