Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization.

@article{Sottoriva2013SinglemoleculeGD,
  title={Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization.},
  author={Andrea Sottoriva and Inmaculada Spiteri and Darryl Shibata and Christina A. Curtis and Simon Tavar{\'e}},
  journal={Cancer research},
  year={2013},
  volume={73 1},
  pages={
          41-9
        }
}
Substantial evidence supports the concept that cancers are organized in a cellular hierarchy with cancer stem cells (CSC) at the apex. To date, the primary evidence for CSCs derives from transplantation assays, which have known limitations. In particular, they are unable to report on the fate of cells within the original human tumor. Because of the difficulty in measuring tumor characteristics in patients, cellular organization and other aspects of cancer dynamics have not been quantified… CONTINUE READING

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