Single-molecule fluorescence methods for the study of nucleic acids.

@article{Ha2001SinglemoleculeFM,
  title={Single-molecule fluorescence methods for the study of nucleic acids.},
  author={Taekjip Ha},
  journal={Current opinion in structural biology},
  year={2001},
  volume={11 3},
  pages={287-92}
}
  • Taekjip Ha
  • Published 2001 in Current opinion in structural biology
Single-molecule fluorescence methods and biomechanical tools provide exciting new opportunities to probe biochemical processes in unprecedented detail. The detection and spectroscopy of single fluorophores have recently been used to observe conformational changes and biochemical events involving nucleic acids. A number of fluorescence observables, including localization, quenching, polarization response and fluorescence resonance energy transfer, have been utilized. An exciting new opportunity… CONTINUE READING

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