Single-molecule detection of biomolecules by surface-enhanced coherent anti-Stokes Raman scattering.

Abstract

We report on the applicability of combining surface-enhanced Raman scattering (SERS) with coherent anti-Stokes Raman scattering for high-sensitivity detection of biological molecules. We found that this combination of techniques provides more than 3 orders of signal enhancement compared with SERS and permits monitoring of biological molecules such as deoxyguanosine monophosphate (dGMP) and deoxyadenosine monophosphate at the single-molecule level. This combined technique also improved detection sensitivity for angiotensin peptide. As this is believed to be the first report of detection of dGMP at the single-molecule level, we suggest that this approach can serve as a new tool for biological studies.

Cite this paper

@article{Koo2005SinglemoleculeDO, title={Single-molecule detection of biomolecules by surface-enhanced coherent anti-Stokes Raman scattering.}, author={Tae-Woong Koo and Selena Chan and Andrew A. Berlin}, journal={Optics letters}, year={2005}, volume={30 9}, pages={1024-6} }