Single microtubules and small networks become significantly stiffer on short time-scales upon mechanical stimulation

@article{Koch2017SingleMA,
  title={Single microtubules and small networks become significantly stiffer on short time-scales upon mechanical stimulation},
  author={Matthias D. Koch and Natalie Schneider and Peter Nick and Alexander Rohrbach},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
The transfer of mechanical signals through cells is a complex phenomenon. To uncover a new mechanotransduction pathway, we study the frequency-dependent transport of mechanical stimuli by single microtubules and small networks in a bottom-up approach using optically trapped beads as anchor points. We interconnected microtubules to linear and triangular geometries to perform micro-rheology by defined oscillations of the beads relative to each other. We found a substantial stiffening of single… 
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