Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase.

@article{Clay2010SinglemarkerIO,
  title={Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase.},
  author={Matthew R. Clay and Mark Tabor and John Henry Owen and Thomas E. Carey and Carol R Bradford and G T Wolf and Max S. Wicha and Mark Edward Prince},
  journal={Head & neck},
  year={2010},
  volume={32 9},
  pages={
          1195-201
        }
}
BACKGROUND In accord with the cancer stem cell (CSC) theory, only a small subset of cancer cells are capable of forming tumors. We previously reported that CD44 isolates tumorigenic cells from head and neck squamous cell cancer (HNSCC). Recent studies indicate that aldehyde dehydrogenase (ALDH) activity may represent a more specific marker of CSCs. METHODS Six primary HNSCCs were collected. Cells with high and low ALDH activity (ALDH(high)/ALDH(low)) were isolated. ALDH(high) and ALDH(low… CONTINUE READING
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