Single injection of P-selectin or P-selectin glycoprotein ligand-1 monoclonal antibody blocks neointima formation after arterial injury in apolipoprotein E-deficient mice.

@article{Phillips2003SingleIO,
  title={Single injection of P-selectin or P-selectin glycoprotein ligand-1 monoclonal antibody blocks neointima formation after arterial injury in apolipoprotein E-deficient mice.},
  author={J. William Phillips and Kurt G. Barringhaus and John M. Sanders and Sean E Hesselbacher and Ann C. Czarnik and David Manka and Dietmar Vestweber and Klaus F Ley and Ian J. Sarembock},
  journal={Circulation},
  year={2003},
  volume={107 17},
  pages={
          2244-9
        }
}
BACKGROUND Emerging data suggest that P-selectin, by controlling adhesion of white blood cells, may be important in limiting the response to vascular injury. METHODS AND RESULTS We tested the hypothesis that transient inhibition of P-selectin with either anti-P-selectin monoclonal antibody (mAb) or anti-P-selectin glycoprotein ligand-1 (PSGL-1) mAb would reduce neointima formation in the setting of carotid denudation injury in atherosclerosis-prone apolipoprotein E-/- mice. Neointima… CONTINUE READING

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