Single high-dose dexamethasone and sodium salicylate failed to attenuate phosgene-induced acute lung injury in rats.

@article{Liu2014SingleHD,
  title={Single high-dose dexamethasone and sodium salicylate failed to attenuate phosgene-induced acute lung injury in rats.},
  author={Fangfang Liu and Juergen Pauluhn and Hubert Truebel and Chen Wang},
  journal={Toxicology},
  year={2014},
  volume={315},
  pages={17-23}
}
Life-threatening acute lung injury potentially occurs following high-level accidental exposures to phosgene gas. This situation was mirrored in rats exposed nose-only at 900-1000 mg phosgene/m(3)min. At this exposure level, previous studies on rats demonstrated sustained reflexively induced cardiopulmonary dysfunction and evidence of vascular fluid redistribution. These findings challenge the currently applied treatment strategies to mitigate the presumed non-cardiogenic lung edema by steroidal… CONTINUE READING