Single granule pH cycling in antigen-induced mast cell secretion.

  title={Single granule pH cycling in antigen-induced mast cell secretion.},
  author={Rebecca M. E. Williams and Watt W. Webb},
  journal={Journal of cell science},
  volume={113 Pt 21},
The pH cycling of individual granules in secreting (serotonin-loaded) mast cells is quantitatively examined using multicolor multiphoton fluorescence microscopy. A typical exocytosis event consists of maximal calcium rise at time zero, granule alkalization a few seconds later and, finally, complete contents release at a fraction of a second after alkalization. Membrane fusion is either transient, as indicated by subsequent granule reacidification, or 'full', as indicated by a granule… CONTINUE READING
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Zn2+ on insulin secretion in pancreatic beta cells

  • J. Barasch, M. D. Gershon, E. A. Nunez, H. Tamir, Q. Al-Awqati
  • J. Biol
  • 1988
Highly Influential
5 Excerpts

Effect of compounds which disrupt proton gradients on secretion of neurosecretory proteins from PC 12 pheochromocytoma cells

  • S. Sankaranarayanan, T. Ryan
  • Neurosci .
  • 2000
1 Excerpt

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