Single fibril growth kinetics of α-synuclein.

@article{Wrdehoff2015SingleFG,
  title={Single fibril growth kinetics of α-synuclein.},
  author={Michael M. W{\"o}rdehoff and O. Bannach and Hamed Shaykhalishahi and A. Kulawik and Stephanie Schiefer and D. Willbold and W. Hoyer and E. Birkmann},
  journal={Journal of molecular biology},
  year={2015},
  volume={427 6 Pt B},
  pages={
          1428-1435
        }
}
Neurodegenerative disorders associated with protein misfolding are fatal diseases that are caused by fibrillation of endogenous proteins such as α-synuclein (α-syn) in Parkinson's disease (PD) or amyloid-β in Alzheimer's disease. Fibrils of α-syn are a major pathological hallmark of PD and certain aggregation intermediates are postulated to cause synaptic failure and cell death of dopaminergic neurons in the substantia nigra. For the development of therapeutic approaches, the mechanistic… Expand
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References

SHOWING 1-10 OF 48 REFERENCES
The fold of α-synuclein fibrils
  • 405
  • PDF
Dependence of α-synuclein aggregate morphology on solution conditions
  • 347
  • PDF
Rapid self-assembly of alpha-synuclein observed by in situ atomic force microscopy.
  • 49
  • Highly Influential
Direct Observation of Aβ Amyloid Fibril Growth and Inhibition
  • 179
  • Highly Influential
Role of alpha-synuclein carboxy-terminus on fibril formation in vitro.
  • 154
Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
  • 543
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
  • 1,440
  • PDF
Different Species of α-Synuclein Oligomers Induce Calcium Influx and Seeding
  • 543
  • PDF
...
1
2
3
4
5
...