Single-dose versus two-dose dexamethasone effects on lung inflammation and airway reactivity in meconium-instilled rabbits.

@article{Mokra2007SingledoseVT,
  title={Single-dose versus two-dose dexamethasone effects on lung inflammation and airway reactivity in meconium-instilled rabbits.},
  author={Daniela Mokra and Juraj Mokr{\'y} and Anna Drgov{\'a} and Janka Bulikova and M{\'a}ria Petr{\'a}skov{\'a} and Andrea Calkovska},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2007},
  volume={58 Suppl 5 Pt 1},
  pages={379-87}
}
Two doses of the corticosteroid dexamethasone may alleviate meconium-induced acute lung injury more effectively than a single dose. Meconium-instilled rabbits intravenously received dexamethasone (0.5 mg/kg) at one dose 0.5 hours after meconium instillation or at two doses 0.5 hours and 2.5 hours after meconium instillation or were left without treatment… CONTINUE READING