Single dose testosterone increases total cholesterol levels and induces the expression of HMG CoA Reductase

@inproceedings{Grevik2012SingleDT,
  title={Single dose testosterone increases total cholesterol levels and induces the expression of HMG CoA Reductase},
  author={Nina G{\aa}revik and Cristine Skogastierna and Anders Rane and Lena Ekstr{\"o}m},
  booktitle={Substance Abuse Treatment, Prevention, and Policy},
  year={2012}
}
  • Nina Gårevik, Cristine Skogastierna, +1 author Lena Ekström
  • Published in
    Substance Abuse Treatment…
    2012
  • Medicine
  • BackgroundCholesterol is mainly synthesised in liver and the rate-limiting step is the reduction of 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) to mevalonate, a reaction catalysed by HMG-CoA reductase (HMGCR). There is a comprehensive body of evidence documenting that anabolic-androgenic steroids are associated with deleterious alterations of lipid profile. In this study we investigated whether a single dose of testosterone enanthate affects the cholesterol biosynthesis and the expression of… CONTINUE READING

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