Single dose systemic antibiotic prophylaxis of surgical wound infections.

  title={Single dose systemic antibiotic prophylaxis of surgical wound infections.},
  author={Joseph T Dipiro and Ramsey Cheung and Talmadge A Bowden and J A Mansberger},
  journal={American journal of surgery},
  volume={152 5},
The proper duration of antimicrobial use for the prevention of postoperative surgical infection has been a subject of controversy. Currently, more than 40 published clinical trials are available in which the efficacy of single dose surgical prophylaxis with parenteral antimicrobials has been studied. These studies have compared single doses versus multiple doses of the same agent, single doses of antimicrobial versus placebo, single doses of various antimicrobials, and a single dose of one… CONTINUE READING


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