Single-dose safety, pharmacokinetics, and food effects studies of compound naphthoquine phosphate tablets in healthy volunteers.

@article{Qu2010SingledoseSP,
  title={Single-dose safety, pharmacokinetics, and food effects studies of compound naphthoquine phosphate tablets in healthy volunteers.},
  author={Heng Qu and Hong Zhi Gao and Guang Tao Hao and Yuan Yuan Li and Hai Yan Li and Jin Hu and Xiao Fang Wang and Wei Liu and Ze Yuan Liu},
  journal={Journal of clinical pharmacology},
  year={2010},
  volume={50 11},
  pages={1310-8}
}
The compound naphthoquine phosphate is a novel antimalaria drug tablet containing a fixed-dose combination of naphthoquine phosphate and artemisinin in a 1:2.5 ratio. A randomized, open study on the safety and tolerability was conducted in 28 healthy male volunteers using a single oral dose of 350 mg, 700 mg, 1400 mg, or 2100 mg of artemisinin-naphthoquine phosphate. Pharmacokinetics at the last 3 doses were examined in 30 volunteers. Food effects were also determined. Serial blood samples up… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…