Single dose pharmacokinetics of trazodone in healthy subjects.

@article{Nilsen1992SingleDP,
  title={Single dose pharmacokinetics of trazodone in healthy subjects.},
  author={Odd Georg Nilsen and Ola Dale},
  journal={Pharmacology & toxicology},
  year={1992},
  volume={71 2},
  pages={
          150-3
        }
}
Eight healthy subjects were administered trazodone-HCl orally (100 mg) with and without food and by infusion in a three way cross-over study. Unchanged trazodone was determined in serum and urine by high performance liquid chromatography after an alkaline extraction. Absorption of trazodone was irregular in fasting subjects and improved after food intake. Food intake significantly decreased the maximum serum concentrations of trazodone from 1.88 +/- 0.42 to 1.47 +/- 0.16 micrograms/ml, and… CONTINUE READING

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