Single-dose pharmacokinetics of ampicillin and tobramycin administered by hypodermoclysis in young and older healthy volunteers.

@article{Champoux1996SingledosePO,
  title={Single-dose pharmacokinetics of ampicillin and tobramycin administered by hypodermoclysis in young and older healthy volunteers.},
  author={Nathalie Champoux and Patrick du Souich and Madeleine Ravaoarinoro and D Phaneuf and J B Latour and J R Cusson},
  journal={British journal of clinical pharmacology},
  year={1996},
  volume={42 3},
  pages={325-31}
}
1. To test the feasibility of administering antibiotics by subcutaneous infusion to the elderly, we compared the pharmacokinetics of tobramycin (single dose of 80 mg) given by hypodermoclysis (HDC) with the kinetics of the antibiotic injected intravenously (i.v.) in 10 young (< 50 years old) and 10 elderly (> 65 years old) healthy volunteers. Similar studies were performed with ampicillin (single dose of 1 g) in 12 young and 10 older healthy volunteers. 2. Compared with the i.v. route, HDC… CONTINUE READING