Single dose pharmacokinetics and bioavailability of butyryl glucosamine in the rat.

@article{AghazadehHabashi2006SingleDP,
  title={Single dose pharmacokinetics and bioavailability of butyryl glucosamine in the rat.},
  author={Ali Aghazadeh-Habashi and Alyaa Farouk Abd El-Fattah Ibrahim and John Carran and Tassos P. Anastassiades and Fakhreddin Jamali},
  journal={Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques},
  year={2006},
  volume={9 3},
  pages={359-64}
}
PURPOSE To study single dose pharmacokinetics and bioavailability of the synthetic glucosamine analogue, N-butyryl glucosamine (GLcNBu) after different routes of administration, and also the effect of food following oral doses of GLcNBu in the rat, and stability and absorption of GLcNBu across the rat everted intestine. METHOD GLcNBu was administered intravenously (i.v.), intraperitoneally (i.p.) and orally. Effect of food was studied following oral administration only. Single doses of 223 mg… CONTINUE READING

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